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Birthmarks and Vascular Anomalies Center
BVAC Physicians and Staff
Information About Vascular Anomalies
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Recent publications and/or studies conducted


Dr. Frieden is founder of the Hemangioma Investigator Group, a group of 7 centers which are studying infantile hemangiomas. The group recently enrolled a cohort of 1056 infants and are currently analyzing data for future publications and studies. Dr. Frieden is also the Principal Investigator for a proposed NIH Research Workshop on Infantile Hemangiomas which is planned for April, 2005.

A Retropective study of Clinical Characteristics and Management of Vascular Anomalies: Findings of a Multidisciplinary Vascular Anomalies Clinic was recently performed by Erin F.D. Mathes, a UCSF medical student with Anita N. Haggstrom, MD, Christopher Dowd, MD, William Y. Hoffman, MD, and Ilona J. Frieden, MD

Publications (2001 - present):

  • Tsang MW, Garzon MC, Frieden IJ. How to measure a growing hemangioma and assess response to therapy. Pediatr Dermatol. 2006 Mar-Apr;23(2):187-90.
  • Metry DW, Haggstrom AN, Lucky A, Mancini AJ, Newell B, Nopper A, Heyer G, Frieden IJ. A prospective study of PHACE syndrome in infantile hemangiomas: demographic features, clinical findings, and complications. Am J Med Genet A. 2006 May 1;140(9):975-86.
  • Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development.
    Pediatrics. 2006 Mar;117(3):698-703.
  • Witman PM, Wagner AM, Scherer K, Waner M, Frieden IJ. Complications following pulsed dye laser treatment of superficial hemangiomas. Lasers Surg Med. 2006 Feb;38(2):116-23.
  • Frieden IJ, Haggstrom AN, Drolet BA, Mancini AJ, Friedlander SF, Boon L, Chamlin SL, Baselga E, Garzon MC, Nopper AJ, Siegel DH, Mathes EW, Goddard DS, Bischoff J, North PE, Esterly NB. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA. Pediatr Dermatol. 2005 Sep-Oct;22(5):383-406.
  • Ranchod TM, Frieden IJ, Fredrick DR. Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence. Br J Ophthalmol. 2005 Sep;89(9):1134-8.
  • Miller T, Frieden IJ. Hemangiomas: new insights and classification. Pediatr Ann. 2005 Mar;34(3):179-87.
  • Garzon MC, Lucky AW, Hawrot A, Frieden IJ. Ultrapotent topical corticosteroid treatment of hemangiomas of infancy.
    J Am Acad Dermatol. 2005 Feb;52(2):281-6.
  • Frieden IJ. Risk stratification in hemangiomas of infancy.
    Lymphat Res Biol. 2003;1(4):313-6.
  • Chiller KG, Frieden IJ, Arbiser JL. Molecular pathogenesis of vascular anomalies: classification into three categories based upon clinical and biochemical characteristics. Lymphat Res Biol. 2003;1(4):267-81.
  • Mathes EF, Haggstrom AN, Dowd C, Hoffman WY, Frieden IJ. Clinical characteristics and management of vascular anomalies: findings of a multidisciplinary vascular anomalies clinic. Arch Dermatol. 2004 Aug;140(8):979-83.
  • Haggstrom AN, Frieden IJ. Hemangiomas: past, present, and future. J Am Acad Dermatol. 2004 Jul;51(1 Suppl):S50-2.
  • Metry DW, Hawrot A, Altman C, Frieden IJ. Association of solitary, segmental hemangiomas of the skin with visceral hemangiomatosis. Arch Dermatol. 2004 May;140(5):591-6.
  • Metry DW, Dowd CF, Barkovich AJ, Frieden IJ. Facial hemangioma and cerebral corticovascular dysplasia: a syndrome associated with epilepsy. Neurology. 2003 Nov 25;61(10):1461; author reply 1461.
  • Bruckner A, Frieden IJ. Hemangiomas of infancy. J Am Acad Dermatol. 2003 Apr;48(4):477-93.
  • Kundu RV, Frieden IJ. Presence of vascular anomalies with congenital hemihypertrophy and Wilms tumor: an evidence-based evaluation. Pediatr Dermatol. 2003 May-Jun;20(3):199-206.
  • Chiller KG, Passaro D, Frieden IJ. Hemangiomas of infancy: clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch Dermatol. 2002 Dec;138(12):1567-76.
  • Hand JL, Frieden IJ. Vascular birthmarks of infancy: resolving nosologic confusion. Am J Med Genet. 2002 Apr 1;108(4):257-64.
  • Sugarman JL, Mauro TM, Frieden IJ. Treatment of an ulcerated hemangioma with recombinant platelet-derived growth factor.
    Arch Dermatol. 2002 Mar;138(3):314-6.
  • North PR, Waner M, James CA, Mizeracki A, Frieden IJ, Mihm MC Jr. Congenital nonprogressive hemangioma: a distinct clinicopathologic entity unlike infantile hemangioma. Arch Dermatol. 2001 Dec;137(12):1607-20.
  • Metry DW, Dowd CF, Barkovich AJ, Frieden IJ. The many faces of PHACE syndrome. J Pediatr. 2001 Jul;139(1):117-23. Review. Erratum in: J Pediatr 2001 Sep;139(3):470.
  • Acosta FL Jr, Dowd CF, Chin C, Tihan T, Ames CP, Weinstein PR. Current treatment strategies and outcomes in the management of symptomatic vertebral hemangiomas. Neurosurgery. 2006 Feb;58(2):287-95; discussion 287-95.
  • Du R, McDermott MW, Dowd CF, Young WL, Lawton MT. Neurosurgery at the crossroads: integrated multidisciplinary management of 449 patients with brain arteriovenous malformations. Clin Neurosurg. 2005;52:177-91.
  • Caragine LP Jr, Halbach VV, Dowd CF, Higashida RT. Intraorbital arteriovenous fistulae of the ophthalmic veins treated by transvenous endovascular occlusion: technical case report.
    Neurosurgery. 2006 Feb;58(1 Suppl):ONS-E170.
  • Du R, Dowd CF, Johnston SC, Young WL, Lawton MT. Interobserver variability in grading of brain arteriovenous malformations using the Spetzler-Martin system. Neurosurgery. 2005 Oct;57(4):668-75.
  • Martin AJ, Saloner DA, Roberts TP, Roberts H, Weber OM, Dillon W, Cullen S, Halbach V, Dowd CF, Higashida RT. Carotid stent delivery in an XMR suite: immediate assessment of the physiologic impact of extracranial revascularization. AJNR Am J Neuroradiol. 2005 Mar;26(3):531-7.
  • Dowd CF, Halbach VV, Higashida RT. Meningiomas: the role of preoperative angiography and embolization. Neurosurg Focus. 2003 Jul 15;15(1):E10.
  • Fullerton HJ, Aminoff AR, Ferriero DM, Gupta N, Dowd CF. Neurodevelopmental outcome after endovascular treatment of vein of Galen malformations. Neurology. 2003 Nov 25;61(10):1386-90.
  • Caragine LP Jr., Halbach VV, Ng PP, Dowd CF. Vascular myelopathies-vascular malformations of the spinal cord: presentation and endovascular surgical management.
    Semin Neurol. 2002 Jun;22(2):123-32.
  • Halim AX, Singh V, Johnston SC, Higashida RT, Dowd CF, Halbach VV, Lawton MT, Gress DR, McCulloch CE, Young WL; UCSF BAVM Study Project Brain Arteriovenous Malformation. Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centers.
    Stroke. 2002 Mar;33(3):675-9.
Updated: November 30, 2007
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